Her biggest success in the early stages of her career was Chandramukhi. Nayanthara was cast opposite Rajinikanth and she played the role of Durga. The song Konja Neram from the movie went on to become a chart topper. The movie was directed by P Vasu and Jyothika played the lead.
Nayanthara’s acting skills were very prominent in E. The movie directed by National award winning filmmaker Jananathan had Jiiva play the male lead. She donned the role of a bar dancer and had a meaty share in the movie and her performance was acclaimed.