Her next project was opposite Superstar Rajinikanth! She was paired as second heroine in the blockbuster movie Chandramuki, which went on to run for 800 days! This success instantly made her the most sought after celebrity!
She was then cast in an important role in A.R. Murugadoss’s Ghajini starring Surya, which too was a mega hit and was remade in Hindi with Aamir Khan in the lead.
In 2007 Nayanthara was cast in the much hyped movie, Billa opposite Ajith.